Silencing of UCHL1 by CpG Promoter Hyper-methylation is Associated with Metastatic Gastroenteropancreatic Well-Differentiated Neuroendocrine (Carcinoid) Tumors
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چکیده
منابع مشابه
Efficacy of Galium-68 DOTATATE PET/CT in the Detection of Metastasis Rate of Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors
Objective(s): The aim of this study was to determine metastasis rate in patients with well-differentiated grade1 (G1) and grade 2 (G2) gastroenteropancreatic neuroendocrine tumors (GEP NETs) using the gallium-68 DOTATATE positron emission tomography/computed tomography (68Ga-DOTATATE PET/CT). This study was also targeted toward investigating the relationship of maximum...
متن کاملReporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation
Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a Knockout Mouse Project allele containing both a LacZ reporter gene driven by the native promoter and a neo selection cassette. Messenger RNA levels of the reporter gene and targeted gene were assessed...
متن کاملInitial treatment of well-differentiated neuroendocrine tumors.
Neuroendocrine tumors (NETs) are a broad family of tumors classified by site of origin and histologic characteristics. Per a Surveillance, Epidemiology and End Results (SEER) database analysis, the incidence of NETs in the United States was estimated to be 5.25/100,000 in 2004; this was likely an underestimation, given that these tumors often go unreported or undiagnosed.[1] Bronchial carcinoid...
متن کاملIdentification of primary tumors in patients presenting with metastatic gastroenteropancreatic neuroendocrine tumors.
BACKGROUND Patients with gastroenteropancreatic neuroendocrine tumors often present with metastases. Identification of the primary tumor is important for operative management, and therefore we sought to determine our success at identifying primary tumors with diagnostic testing and operative exploration. METHODS A clinical neuroendocrine tumor database was reviewed to identify patients presen...
متن کاملGastroenteropancreatic neuroendocrine tumors (GEP-NETS)
1 Medical Student, Universidad de Antioquia, Medellín, Colombia. Gastrohepatology Group. Universidad de Antioquia. Medellín, Colombia. email: crivargas@ gmail.com 2 Gastrointestinal Surgeon and Endoscopist, Hospital Pablo Tobón Uribe, Medellín, Colombia. Professor of Surgery, Universidad Pontificia Bolivariana. Medellín, Colombia. Gastrohepatology Group. Universidad de Antioquia, Medellín, Colo...
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ژورنال
عنوان ژورنال: Annals of Surgical Oncology
سال: 2014
ISSN: 1068-9265,1534-4681
DOI: 10.1245/s10434-014-3787-2